Ten-man AFC Bournemouth held on for a memorable Old Trafford point - their first ever at Manchester United - as a terrific rearguard action earned the Cherries a 1-1 draw.
Marcos Rojo gave the hosts the lead midway through the half as he redirected a shot following a corner, the Cherries levelling before the break through Joshua King's penalty.
Andrew Surman was shown a second yellow card before the break and after Zlatan Ibrahimovic had a penalty saved by Artur Boruc, Bournemouth defended to the hilt to claim their point.
Benik Afobe replaced Jack Wilshere in the only change to the Bournemouth starting line up. Wilshere took a place on the Old Trafford bench, joined by Jordon Ibe who returned to the squad after a knee injury.
Talk pre-match was of illness to Eddie Howe, a sickness bug meaning the Cherries manager was unable to come to the game until just before kick off.
United had the game's first chance when Antonio Valencia seized on a loose ball and crossed for Wayne Rooney, but the striker's header landed on the roof of Boruc's net.
After King shrugged Phil Jones off the ball and moved into the box the forward was unable to find a cutback for Marc Pugh to convert.
A rapid-fire opening then saw United break with Paul Pogba suddenly haring down on goal; with Adam Smith chasing back the France international's low shot was well saved by Boruc.
Ten minutes in and huge chances fell at both ends. Tyrone Mings' backpass was cut out by Rooney but between the England captain and Ibrahimovic United couldn't convert.
From the clearance Afobe was clean through on goal and past Rojo, facing David De Gea the striker stumbled and the hosts cleared.
Boruc blocked an Anthony Martial shot and five minutes later the same situation won United a corner; the Cherries defence standing firm under mounting pressure.
On 23 minutes the visiting resistance was broken as United took the lead.
Adam Smith was off the field receiving treatment as a corner swung in. Half cleared, Valencia drove in a low effort which Rojo converted from inside the area.
Some promising Cherries attacking allowed Charlie Daniels and Pugh to exchange passes in the United area, the full-back's cross claimed by De Gea.
A golden opportunity came the Cherries' way as they won a penalty, successfully converted to tie the score.
Pugh cut back his dribble deep in the United area, his legs taken away by Jones' challenge. Former Red Devil King stepped up and converted with confidence from the spot.
Boruc was tested by Ibrahimovic's shot from outside the area, saving well, before a flash point at the end of the half.
Attacking a cross, Ibrahimovic appeared to catch Mings with an arm and in the altercation that followed Surman clashed with the Swede, and was duly shown a red card by referee Kevin Friend.
Dan Gosling replaced Pugh at the interval, with the hosts pushing to retake the lead against the under-manned Cherries from the start of the second period.
A brave block deflected Rooney's effort over the bar ahead of a succession of United corners which defended successfully.
Boruc again came the rescue, clawing behind Pogba's long-range strike as the Cherries started to build their way into the half.
Jose Mourinho shuffled his pack 20 minutes from time with a triple substitution: Marouane Fellaini, Marcus Rashford and Jesse Lingard.
Moments after the switch United won a penalty when Adam Smith was adjudged to have handled following Pogba's volleyed cross.
However, Ibrahimovic's spot kick was saved brilliantly by Boruc, diving low to his right to push the Swede's penalty away.
Pogba had a free kick that cleared the goal, the match becoming increasingly niggly as the Cherries looked to hold on to their precious point.
Into the final ten minutes the home fans were becoming increasingly restless and the Cherries were digging in to stifle home attacks.
Baily Cargill was introduced for his first ever Premier league appearance amongst bodies being thrown in the way of every tackle in the five minutes of added time.
The ball bobbling around the Cherries' area, Pogba's shot was scrambled away; Howe's men confirming their point in front of 2,400 jubilant travelling supporters.