Jamie Ward’s 61st minute strike was the difference between the two sides as the Cherries were beaten 1-0 by Derby County at the Goldsands Stadium.
Eddie Howe’s team had decent chances in both halves with Tokelo Rantie and Eunan O’Kane both going close, but they couldn’t prevent the Rams from claiming all three points.
Ward scored the winner against the run of play when he forced his shot past on loan goalkeeper Lee Camp from close range.
Both Ryan Fraser and Matt Ritchie came on as late substitutes and gave the hosts a new attacking impetus, only for Steve McClaren’s team to hold firm.
Shaun MacDonald and Tommy Elphick replaced Harry Arter and Elliott Ward in the starting line-up, with the pair missing the game with calf injuries.
But there were notable returns to the squad for wingers Fraser and Ritchie, who started on the bench.
While chances were few and far between in the opening stages, the game was shaping up to be a competitive encounter that wouldn’t remain goalless for long.
Derby arrived at the Goldsands Stadium as one of the division’s in-form teams and looked full of confidence as they created an opening for Chris Martin, who saw his half volley tipped over by Camp.
Rantie, who helped South Africa beat Spain on Wednesday, then went close, seeing his shot from a narrow angle saved at the near post.
But the visitors had the better of the late chances in the first half with Camp holding on to Ward’s low effort and Simon Dawkins clipping the top of the bar.
The Cherries started the second half well and Brett Pitman narrowly missed the target after darting to the near post to meet a low cross following the restart.
However, Derby took the lead in the 61st minute through Ward. Camp got a hand on the close range strike, but couldn’t prevent the Northern Ireland international from opening the scoring.
Howe responded by sending on Fraser and Ritchie in a double substitution, with Marc Pugh and Rantie coming off.
Their introduction certainly lifted the home crowd and they watched on as O’Kane guided a looping header just over the bar.
Substitute Wes Thomas then got in behind the defence and crossed for Fraser, who directed his header wide of the mark.
As the Cherries piled on the pressure, Derby countered through Mason Bennett but he was denied by a good save from Camp.
Howe then lost Steve Cook to injury in added on time as the defender left the pitch on a stretcher following a collision on the edge of the Derby area.
Cherries: Camp, Francis, Cook, Elphick, Daniels, Grabban, O'Kane, MacDonald, Pugh (Fraser 63), Rantie (Ritchie 64), Pitman (Thomas 74).
Unused substitutes: Flahavan, Addison, Harte, Surman.
Booked: Francis, Cook
Derby County: Grant, Wisdom, Buxton, Keogh, Forsyth, Bryson, Hughes, Eustace, Ward (Russell 79), Martin (Sammon 87), Dawkins (Bennett 74)
Unused substitutes: Morch, Smith, Davies, Ball.
Booked: Buxton, Hughes
Goal: Ward (61)
Attendance: 10, 720 (1,391 Derby County supporters)